Ucwaningo oluningi lokuqala lubonise ukushintshela kugwayi we-elekthronikhi ekubhemeni ugwayi kuyindlela enempilo kwababhemayo abayimilutha. Yingakho ama-e-cigarette amaningi adayiswa njengezinye izindlela ezinempilo emikhiqizweni kagwayi futhi ababhemayo bayelulekwa ukuba bashintshele kulawa ma-e-cigarettes njengesinyathelo sokuyeka umkhuba.
Kodwa-ke, ucwaningo olusha olwenziwe yiNyuvesi yaseCalifornia, e-Riverside lubonisa ukuthi i-e-cigarettes ingase ingabi nempilo njengoba senziwa ukuba sikholwe. Ngokocwaningo eshicilelwe kuJournal of Toxics, abacwaningi bathola ukuthi ukusuka emikhiqizweni kagwayi evamile ukuya kugwayi we-electronic akusizi ekubuyiseleni i-epithelium yamakhala kwababhemayo. Abacwaningi bathola ukuthi ukusebenzisa ugwayi we-elekthronikhi kubangele izinguquko ezifanayo zamangqamuzana ezimpawu zofuzo njengokubhema ugwayi. Ngakho-ke, ukushintshela ku-e-cigarettes akukwazi ukuguqula i-epithelium yamakhala kumuntu oyeka ugwayi ukuya kulowo ongabhemi.
UDkt. Giovanna Pozuelos, omunye wososayensi abenze lolu cwaningo, uthi "Ngokuqondile, iqembu le-EC libonise ukuguqulwa kwezakhi zofuzo ezihambisana nokwanda kwengcindezi ye-oxidative, ukuphendula kwamasosha omzimba, kanye ne-keratinization, kanye nobufakazi bokungasebenzi kahle kwe-ciliary, nokuncipha kwe-ciliogenesis."
Ithimba labacwaningi eliholwa uprofesa webhayoloji yamaseli I-Prue Talbot kubika ukuthi ukuguqulwa kwamangqamuzana kuphrofayili ye-epithelium gene expression ebangelwa ukushintshela ku-e-cigarettes kungavimbela ukutholakala kwe-epithelium yokuphefumula yabantu ngabanye. Ngakho-ke uProfesa Talbot ukholelwa ukuthi ukusuka ekubhemeni ugwayi uye kugwayi we-elekthronikhi kungenzeka kube nomthelela ekulimaleni kwe-epithelial yokuphefumula esikhundleni sokusiza ekululameni kwawo. Lokhu kungenzeka kuholele ezifweni zokuphefumula ezimbi kakhulu njenge-squamous metaplasia.
NgokukaDkt. pozuelos squamous metaplasia umonakalo odaleka esicutshini esigudle izitho zokuphefumula ezinjengomphimbo, i-Thyroid, namaphaphu. Kubangelwa ukulimala okunobuthi okuhambisana nokubhema ugwayi. Lo monakalo uyalungiseka kodwa, lokhu kungenzeka kuphela uma obhemayo esewuyekile umkhuba.
Ngokocwaningo abantu abasebenzisa i-e-cigarettes babe nokwanda kwezimpawu zamangqamuzana ezixhumene ne-squamous metaplasia. Lokhu kusikisele ukuthi esikhundleni sokuthi i-e-cigarettes isize ekuguquleni i-squamous metaplasia ingase iphazamise inqubo. Nakuba abaningi bekholelwa ukuthi ukushintshela ku-e-cigarettes kuyisinyathelo sokuqala sokuyeka ukubhema. Iqiniso elivela kulolu cwaningo ukuthi akunjalo. Lokhu kungenxa yokuthi akusizi ekwelapheni kokulimala okunobuthi ezicutshini zokuphefumula.
Ukuze baqedele ucwaningo lwabo abacwaningi baseNyuvesi yaseCalifornia Riverside basebenze namaqembu amathathu ababambiqhaza okungababangabhemi, ababhemayo bamanje kanye nababekade bebhema ugwayi abebesebenzisa i-e-cigarette yesizukulwane sesibili ngokuqhubekayo ezinyangeni eziyisithupha ezedlule. Abacwaningi babe sebehlaziya ama-biopsies ekhala aqoqwe kubahlanganyeli eqenjini ngalinye futhi baqhathanisa okutholakele.
INational Institutes of Health, i-FDA Center for Tobacco Products, kanye neNational Institute on Drug Abuse baxhase lolu cwaningo. Okunesihloko esithi “Ubufakazi Bemibhalo Ebhaliwe Bokuthi Ukusuka Kugwayi Kuya Kugwayi We-elekthronikhi Akubuyisi Umonakalo Ku-Epithelium Yokuphefumula,” lolu cwaningo ingeza enkingeni ekhulayo yolwazi manje ekhombisa ukuthi i-e-cigarettes ayinempilo njengoba i-hype emigwaqweni iphakamisa.
