Isitshalo sensangu siqukethe ama-phytocannabinoids angaphezu kwe-120 kanye nama-terpenes angama-500+ wonke abonakala enemiphumela, hhayi nje emzimbeni, kodwa komunye nomunye. Lo mphumela we-synergistic abanawo komunye nomunye ubizwe ngokuthi i-entourage effect.
Njengoba abaningi besebenzisa i-CBD ngokwabo kuyilapho benikeza izinja zabo, amakati, nezinye izilwane ezifuywayo ukuze bathole usizo ngakho konke okuvela ukunciphisa ukukhathazeka ekusekeleni impilo yonke, kuhle kakhulu ukufunda mayelana nokungena nokuphuma komphumela we-entourage. Ngokwenza kanjalo, ungenza imikhiqizo ye-CBD ikusebenzele kangcono wena nezilwane ezifuywayo.
Okuqukethwe
I-Cannabis Cannabinoids Ne-Terpenes Asebenzisana Kanjani
Ukuze siqonde ukuthi ama-cannabinoids nama-terpenes asebenzisana kanjani ukudala umphumela wokugqugquzela, sidinga ukubheka uhlelo lokulawula olubizwa ngokuthi i-endocannabinoid system (ECS).
Yakhiwa ama-cell receptors kanye nama-neurotransmitters aqondiswe kuwo, etshela ingqamuzana ukuthi yisiphi isenzo sokulinganisa okufanele silenze, i-ECS ibalulekile empilweni nasekuphileni. Isibonelo, i-ECS ingasiza ukuzola ukuvuvukala lapho amasosha omzimba ethwele kanzima futhi ekhiqiza izinto eziningi ezivuthayo.
Ezinye zezinhlelo ze-ECS zinendima ebalulekile ekusekeleni zihlanganisa:
- Ukufunda nokukhumbula
- Ukucutshungulwa kwemizwelo
- Sleep
- Ukulawula ukushisa
- Ukulawula ubuhlungu
- Izimpendulo zokuvuvukala kanye nokuzivikela komzimba
- Ukudla kanye nesifiso sokudla
Ama-Cannabinoid nama-terpenes athonya imiphumela yomunye nomunye ku-ECS nakwamanye ama-receptors abalulekile, njengama-serotonin receptors, ngezindlela eziningana.
Umphumela Wokuhlangana: Isibonelo 1
Enye yezindlela eziyinhloko ama-phytocompounds athonyana ngayo ngokubopha kuma-receptors ngaphambi kokuba enye inhlanganisela ikwazi. Lokhu kungavimba i-cannabinoid noma i-terpene ngokuphelele, kuyivumele ukuthi ihambe iyofuna ama-receptors angaboshiwe. Futhi, zingabangela ukuvinjelwa ingxenye, ukuvimbela enye i-phytocompound ekubopheni ngokugcwele isamukeli.
Ngaphezu kwalokho, ama-cannabinoids nama-terpenes womabili ama-agonists kanye nabaphikisi kuma-receptors ahlukene. I-agonist izokwenza kusebenze ama-receptors futhi ingavimba ezinye izinhlanganisela ekubopheni ngenxa yazo ngokuthatha izindawo ezibophayo.
Umphikisi udlulela phambili, nokho. Ayigcini nje ngokususa indawo ebophayo kwenye i-cannabinoid, kodwa ingavimbela isamukeli ukuthi sicushwe ngisho noma kunezindawo ezibophayo ezitholakalayo.
Umphumela Wokuhlangana: Isibonelo 2
Izithako ze-cannabis, ikakhulukazi i-terpenes, zitholwe ukuthi zithonya umgoqo wegazi nobuchopho ngokunciphisa ukumelana nokubuyisela amandla. Lokhu kusiza ama-cannabinoids afana ne-cannabidiol (CBD) ukuthi adlule kalula, okuholela emazingeni aphansi kanye nobubanzi obukhulu namandla emiphumela.
Isibonelo, ama-cannabinoids awadingi ukudlula umgoqo wegazi nobuchopho ukuze avule izici zawo zokudambisa izinhlungu, kodwa akwenza kakhulu uma sifuna imiphumela yawo ye-antinociceptive phezulu. Ama-Antinociceptive yizinto ezivimbayo ubuhlungu izimpawu ezigabeni ezihlukahlukene endleleni yobuhlungu, kuyilapho ama-analgesics eshintsha umbono wobuhlungu.
I-Entourage Effect Controversy
Ngenkathi ucwaningo seluthole ubufakazi bokuthi izinhlanganisela ze-cannabis zisebenza ndawonye, a Ukubuyekeza kwe-2020 uye wahlehla embonweni wokuthi umphumela we-entourage uhlale uyinto enhle.
Ababhali bokubuyekeza bayaqaphela ukuthi kunomehluko omkhulu phakathi kocwaningo olulinganiselwe lokuthi ingabe umphumela wenxusa uletha ngokuthembekile imiphumela enenzuzo kanye nabakhiqizi be-CBD abamukela ngenhliziyo yonke, ikakhulukazi lapho bemaketha imikhiqizo yabo.
Ngenxa yokuthi kunezingxube eziningi kangaka, eziningi zazo ezibonakala ngokulandela umkhondo nokho zisenethonya, kunzima kakhulu ukunquma ukuthi yimaphi ama-cannabinoids nama-terpenes asebenza kangcono ndawonye futhi ngasiphi isilinganiso.
Ngalezo zinhlanganisela eziningi, inani lezinhlanganisela esingakwazi ukuzenza lingokwezinkanyezi, futhi lokho akunaki ngisho nokuba izinhlanganisela zivele ngamanani ahlukene (okugxilwa).
Nokho, kubonakala kunjalo i-cannabinoid ihlukanisa ngokuvamile ukukhiqiza imiphumela engalingani. Isibonelo, ukuhlukaniswa kwe-THC kuthambekele kakhulu ekubangeleni i-paranoia, ngoba awekho amanye ama-cannabinoids angaphazamisa ikhono le-THC lokuvuselela ama-receptors e-CB1.
Ngenkathi ama-isolate aqukethe i-CBD adinga imithamo ephezulu kunejwayelekile futhi anemiphumela elinganiselwe uma kuqhathaniswa nemikhiqizo egcwele ye-CBD.
Imuphi Umkhiqizo We-CBD Onomphumela Ongcono Kakhulu Wokuhlangana?
Lapho ufuna umphumela ophelele wokuhlanganisa, imikhiqizo egcwele ye-CBD ivame ukuba phambili, njengoba iqukethe wonke ama-cannabinoids kanye ne-terpenes isitshalo se-cannabis okufanele sinikeze.
Ukukhuthaza Umphumela Omuhle Wokuhlangana
Nakuba sifunde ukuthi umthelela we-entourage uyinto yangempela, siphinde safunda ukuthi akufanele sihlale silinganisa nezinzuzo ezinhle.
Kodwa-ke, ngokuhlolwa okuncane, ungafinyelela kude ekuqinisekiseni ukuthi ihlala iletha okuhle kakhulu. Futhi ungakwenza lokho ngokuxuba nokuqhathanisa imikhiqizo yensangu ndawonye.
Ngaphandle kwalapho wena noma isilwane sakho esifuywayo sizwela i-THC - iningi alinayo - i-CBD ye-spectrum ephelele ingumkhiqizo we-CBD ongcono kakhulu ukuqala ngawo. Futhi ngisho nangemva kwalokho, isanikeza isisekelo esihle.
Uma kukhulunywa ngabantu, isinyathelo esilandelayo esiphusile ukungeza i-THC isolate noma umkhiqizo ogcwele we-THC we-spectrum emiksini. Ngoba ngenkathi i-THC inesibopho esikhulu sokunikeza izitshalo zensangu amandla azo okubangela ukuphakama, kuyelapha kakhulu.
Ama-cannabinoids, ikakhulukazi, i-CBD, asebenza kahle ukuvimba i-THC ekugqugquzeleni ama-receptors amaningi, ithuntubeze noma iqede okuphakeme, kodwa uma wengeza iTHC ku-CBD yakho, imiphumela izofana kakhulu nemiphumela yensangu.
Uma ufuna ukugwema lokho kuphezulu noma ufuna ukuthuthukisa Imiphumela egcwele ye-CBD ye-spectrum yesilwane sakho, i-CBD isolate isebenza kahle. CBG kanye Imikhiqizo ye-CBN ziya ngokuduma futhi zingasebenza njengesengezo esihle kakhulu,
kodwa ukuqapha kuyalulekwa. Ngoba ngenkathi I-CBG futhi i-CBN ayisebenzi ngokwengqondo ngendlela efanayo I-THC, okungukuthi, akubangeli ukuphakama kwe-euphoric, asebenza ngokwengqondo kakhulu kune I-CBD ngenxa yabo bavula ama-receptors ebuchosheni.
Ngokungangabazeki, abaningi bathi i-CBG izizwa njengokujaha kwe-caffeine futhi ibenza bazizwe benobungane, kuyilapho i-CBN ikhuthaza ukuphumula okukhulu nokudambisa.
Ukhiye Ohamba phambili
Uma ufuna umphumela omkhulu wokugqugquzela, i-CBD egcwele ye-spectrum iyona eya kuyo. Kodwa-ke, ukusebenzisa eminye imikhiqizo ye-cannabis ku-tandem kuyindlela enhle yokuhlanganisa umphumela we-entourage nezidingo zakho. Ngakho-ke ungesabi ukuzama, vele uqiniseke ukuthi wenza ucwaningo lwakho kuqala.
